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KMID : 1001020030010030229
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Journal of Urologic Oncology
2003 Volume.1 No. 3 p.229 ~ p.235
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Correlation of Caveolin-1 Expression and Microvessel Density with Metastasis and Prognosis in Conventional Renal Cell Carcinoma
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Oh Dong-Keun
Won Yong-Yeun
Joo Hee-Jae
Min Kyu Choi
Kim Young-Bu
Kim Young-Soo
Kim Se-Joong
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Abstract
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Purpose: To investigate the relationship of caveolin-1 expression and microvessel density(MVD), a reflection of angiogenesis, to metastasis and prognosis in patients with conventional renal cell carcinoma(RCC).
Materials and Methods: Formalin-fixed, paraffin-embedded tissue sections of conventional RCC from 67 patients who had undergone radical nephrectomy were stained immunohistochemically with specific antibodies against caveolin-1 and CD34. Caveolin-1 immunostaining was semi-quantitatively estimated based on proportion and intensity. Caveolin-1 score was generated by multiplication of the values for the two parameters. MVD was determined with CD34 stained slides. The expression pattern of caveolin-1 and MVD was compared with the clinicopathological variables.
Results: Eighteen patients had either synchronous or metachronous metastases and eleven patients died during follow-up. Caveolin-1 intensity was significantly correlated with tumor size, TNM stage, M-stage, grade, and metastasis. Caveolin-1 score was significantly correlated with M-stage and metastasis. Caveolin-1 proportion and MVD were significantly correlated with metastasis. MVD was correlated with caveolin-1 expression. There was no difference in the expression of caveolin-1 and MVD between primary and metastatic sites. The survival of patients with higher caveolin-1 expression was significantly worse than that of patients with lower caveolin-1 expression.
Conclusions: Increased expression of caveolin-1 and MVD is associated with metastasis and a worse prognosis in conventional RCC. Caveolin-1 expression is correlated with MVD. These results suggest that caveolin-1 may play an important role in the progression of conventional RCC and angiogenesis may be affected by caveolin-1 during the progression of RCC.
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KEYWORD
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Caveolin-1, Metastasis, Microvessel density, Prognosis, Renal cell carcinoma
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